Hollywood watchers think vampire romance "The Twilight Saga: New Moon" could take a nearly $100 million(S$139 million) bite from movie theater box offices when it debuts this weekend, and score one of the biggest openings ever for a non-summer film.

"New Moon," which debuts in the United States and Canada on Friday, is independent studio Summit Entertainment's sequel to last year's "Twilight," which surpassed expectations by making $69.6 million in its first weekend.