Drug makes fish go rogue

Anti-anxiety drugs find their way into wastewater where they make fish more fearless and antisocial, with potentially serious ecological consequences, researchers said last week. Scientists examining perch exposed to the sedative Oxazepam - which, like many medications, passes through the human body - found that it made them more likely to leave their school and strike out on their own.

"Normally, perch are shy and hunt in schools. This is a known strategy for survival and growth," said ecologist Tomas Brodin, lead author of the article published in Science.

"But those who swim in Oxazepam became considerably bolder," he said, putting the fish at greater risk of being eaten by predators.

Brodin and other researchers at Sweden's Umea University tested the fish by exposing them to drug concentrations corresponding to those found in wastewater in densely populated areas of the Scandinavian country. In addition to growing bolder, the fish also ate more quickly, which the researchers fear could disrupt the ecological balance.

"In waters where fish begin to eat more efficiently, this can affect the composition of species, for example, and ultimately lead to unexpected effects, such as increased risk of algal blooming," Brodin said.

With the use of such drugs on the rise, in Sweden and elsewhere, the researchers said the changes in the fish could be a global phenomenon, adding that more research is necessary before broad-based conclusions can be drawn.

"The solution to the problem is not to stop medicating ill people but to try to develop sewage treatment plants that can capture environmentally hazardous drugs," said environmental chemist Jerker Fick.

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