Prime Minister Lee Hsien Loong will be travelling to Seoul to attend the second Nuclear Security Summit from March 26 to 27 at the invitation of South Korea's president Lee Myung-bak.
The meeting in Seoul is a follow-up to the inaugural Nuclear Security Summit (NSS) that was held in Washington D.C. in April 2010 which Mr Lee had also attended.
The Seoul Summit will review the progress made in national measure and international cooperation since the last meeting.
The Seoul Summit will also consider the interface between nuclear security and nuclear safety, a pertinent topic following the accident at the Fukushima Daiichi Nuclear Power Plant.
The leaders of 53 countries and four international organisations are expected to participate in the Seoul Summit.
Mr Lee will be accompanied by Mrs Lee, officials from the Prime Minister's Office, the Ministry of Foreign Affairs and the National Environment Agency.
During his absence, Deputy Prime Minister and Coordinating Minister for National Security and Minister for Home Affairs Mr Teo Chee Hean will be the Acting Prime Minister.